Crystallization of paracetamol from solution in the presence and absence of impurity

摘要: The bulk crystallization of paracetamol has been examined under controlled conditions in the presence and absence additive p-acetoxyacetanilide (PAA), as a function both supersaturation levels. induction time to nucleation was found increase with PAA concentration solution. product micro-crystals were characterized for shape strain/defect content using electron optical microscopy X-ray Laue diffraction techniques, respectively. A change crystal habit pure crystals from columnar (dominant [110]) plate-like [001]) observed occur an level, whilst addition invariably led development aspect ratio that varied impurity level supersaturation. HPLC showed be incorporated into average segregation coefficient 14-18% depending on ready incorporation is attributed molecular similarity this molecule host material. shown cause significant mosaic spread, implying crystals. influence probably due its effect blocking critical nucleus. potential implications such variations morphology strain design physical chemical properties resulting particulates are discussed.