Chronic persistent hepatitis and unconjugated hyperbilirubinemia.

作者: Bertram F. Felsher , Noemi M. Carpio

DOI: 10.1016/0016-5085(79)90329-9

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摘要: Abstract The authors studied 12 patients with chronic persistent hepatitis and or intermittent mild unconjugated hyperbilirubinemia. Maximum serum total bilirubin concentration ranged from 2.1 to 3.6 mg/dl. Hemolysis was not evident. Hepatic UDP-glucuronyltransferase activity assayed in each patient 0.16 0.39 U (mean ± SEM=0.27 0.02) compared 0.68–1.99 (1.35 0.08) 23 normals, 0.78–2.28 (1.41 0.05) 53 acute hepatitis, 0.34–1.74 (0.81 0.09) 16 anicteric 0–0.62 (0.24 0.03) 33 Gilbert's syndrome. mean significantly lower but higher than incidence of hyperbilirubinemia among first degree relatives 0:32 icteric 24:85 (28%) These results show that the likely cause for associated is an acquired depression hepatic activity. data suggest enzyme defect related hepatitis.

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