Breast Cancer Metabolism and Mitochondrial Activity: The Possibility of Chemoprevention with Metformin.

摘要: Metabolic reprogramming refers to the ability of cancer cells alter their metabolism in order support increased energy request due continuous growth, rapid proliferation, and other characteristics typical neoplastic cells. It has long been believed that increase metabolic was independent mitochondrial action but recently we know activity together with plays a pivotal role regulation needed for tumor cell growth proliferation. For these reasons mitochondria pathways could be new target therapeutic chemopreventive intervention. Metformin particular is actually considered promising agent against thanks its inhibit complex I.