5 FU infusion with mitomycin-C vs. 5 FU infusion with methyl-CCNU in the treatment of advanced upper gastrointestinal cancer. A Southwest oncology group study

作者: Thomas Buroker , P. N. Kim , Carl Groppe , Joseph McCracken , Robert O'Bryan

DOI: 10.1002/1097-0142(197910)44:4<1215::AID-CNCR2820440408>3.0.CO;2-S

关键词:

摘要: A randomized trial was conducted by the Southwest Oncology Group (SWOG) in advanced carcinoma of stomach and pancreas. Patients were assigned to receive monthly 5-fluorouracil 96-hour continuous infusions with either bolus mitomycin-C or oral methyl-CCNU. Mitomycin-C methyl-CCNU administered every eight weeks. The 5 FU-mitomycin combination produced a 14% 22% response rate disseminated pancreatic carcinoma, respectively. infusion FU achieved responses 9% 5% tumors, There ho significant difference survival between limbs for tumor. Median gastric on regimen 25 weeks vs. 18 FU-methyl-CCNU arm. In median mitomycin limb 19 as compared 17 program. Leukopenia greater first course limb. Regression analysis demonstrated that performance status most important pretreatment characteristic predicting both tumors. Neither appears significantly alter dismal prognosis upper gastrointestinal neoplasms.

参考文章(7)
Laurence H. Baker, Robert W. Talley, Richard Matter, Daniel E. Lehane, B. W. Ruffner, Stephen E. Jones, Francis S. Morrison, Ronald L. Stephens, Edmund A. Gehan, Vainutis K. Vaitkevicius, Phase III comparison of the treatment of advanced gastrointestinal cancer with bolus weekly 5‐FU vs. methyl‐CCNU plus bolus weekly 5‐FU. A southwest oncology group study Cancer. ,vol. 38, pp. 1- 7 ,(1976) , 10.1002/1097-0142(197607)38:1<1::AID-CNCR2820380102>3.0.CO;2-S
Stephen K. Carter, Robert L. Comis, The integration of chemotherapy into a combined modality approach for cancer treatment Cancer Treatment Reviews. ,vol. 2, pp. 193- 214 ,(1975) , 10.1016/S0305-7372(75)80003-X
R. Glen Wiggans, Paul V. Woolley, John S. Macdonald, Tarilyn Smythe, Winston Ueno, Philip S. Schein, Phase II trial of streptozotocin, mitomycin-C and 5-fluorouracil (SMF) in the treatment of advanced pancreatic cancer. Cancer. ,vol. 41, pp. 387- 391 ,(1978) , 10.1002/1097-0142(197802)41:2<387::AID-CNCR2820410201>3.0.CO;2-X
Charles G. Moertel, James A. Mittelman, Richard F. Bakemeier, Paul Engstrom, James Hanley, Sequential and combination chemotherapy of advanced gastric cancer Cancer. ,vol. 38, pp. 678- 682 ,(1976) , 10.1002/1097-0142(197608)38:2<678::AID-CNCR2820380209>3.0.CO;2-S
Thomas R. Buroker, Paik N. Kim, Laurence H. Baker, Voravit Ratanatharathorn, Bonnie Wojtaszak, Vainutis K. Vaitkevicius, Mitomycin-C alone and in combination with infused 5-fluorouracil in the treatment of disseminated gastrointestinal carcinomas Medical and Pediatric Oncology. ,vol. 4, pp. 35- 42 ,(1978) , 10.1002/MPO.2950040107
Robert L. Comis, Stephen K. Carter, A review of chemotherapy in gastric cancer Cancer. ,vol. 34, pp. 1576- 1586 ,(1974) , 10.1002/1097-0142(197411)34:5<1576::AID-CNCR2820340503>3.0.CO;2-0