RELATION BETWEEN QUALITATIVE AND QUANTITATIVE ALTERATIONS IN THYROID HORMONE SYNTHESIS INDUCED BY VARYING DOSES OF IODIDE.

摘要: The effect of varying doses stable sodium iodide on thyroid hormone biosynthesis has been studied in rats. From measurements with 131I, the incorporation iodine into several thyroidal components was determined, both as a proportion administered dose and absolute quantity iodine. In short-term (30-min) experiments, 2 phases response could be distinguished. Over narrow range small doses, proportionate metabolism remained unchanged. this range, percentage uptake organification I31I iodinated amino acids unaltered. total accumulated incorporated mono- diiodotyrosine iodothyronines increased proportional to administered. second phase induced by larger iodide. Here, increasing led progressively severe: 1) decrease mI uptake, 2) pr...