Histogenetic correlations between subcategories of small noncleaved cell lymphomas.

摘要: To assess the biologic relevance of morphologic distinctions between subtypes small noncleaved cell lymphomas (SNCL), ie, sporadic Burkitt's type (sBT) and non-Burkitt's (nBT), we have examined molecular organization several lymphomagenic oncogenes (c-myc, bcl-1, bcl-2) potential pathogenetic contribution Epstein-Barr virus (EBV). Twenty-nine cases SNCL, not associated with immunodeficiency syndromes, were reviewed classified as sBT (18 cases) or nBT (11 without knowledge clinical data. Southern blot analysis 18 sBTs found 17 to contain c-myc rearrangements. Fifteen these comigrated an Ig heavy-chain gene segment, indicating t(8;14) translocation. Chromosome 8 breakpoints clustered in first exon intron gene. 14 mapped JH locus three tumors, S mu nine alpha remaining tumors. Cases involving appeared a more rapid course. All possessed germline bcl-2 bcl-1 fragments. In contrast, 11 nBTs none Rather, 10 evaluable had The seven showed no evidence involvement by any lymphoma-associated oncogene/breakpoint regions studied. EBV genome was detected two one nBT, thus distinguishing feature. These results indicate that subtle histologic differences distinguish subcategories SNCL are significant biologically reflect distinct mechanisms lymphomagenesis. Furthermore, data suggest comprise heterogeneous group respect their genetic composition confirm remarkable homogeneity group.