Evidence for Iron Mismanagement in the Brain in Neurological Disorders

摘要: Studies on manipulation of iron in the diet, both during development and adults, have clearly established that is required for normal neurological function. A deficiency availability to brain may directly affect general metabolic activity by decreasing function cytochrome oxidase, glucose 6-phosphate dehydrogenase, NADH succinic aldehyde dehydrogenase—all which require as an essential cofactor are relatively elevated (Cammer, 1984). Also, rich myelin, biosynthesis cholesterol lipids, key components myelin whose occurs at higher levels than other organs (Larkin Rao, 1990; Pleasure et al., Finally, specific neurotransmitter systems such GABA, dopamine, norepinephrine synthesis (see Chapter 1). The link between dopaminergic dysfunction particularly strong; indeed substantia nigra (SN), site cell bodies brain, iron-rich area (Benkovic Connor, 1993).