Formulation of shear rate sensitive multiple emulsions
作者： V Muguet , M Seiller , G Barratt , O Ozer , J.P Marty
DOI: 10.1016/S0168-3659(00)00314-X
关键词:
摘要: This work mainly concentrates on the formulation of W/O/W multiple emulsions capable breaking and releasing their inner aqueous phase under shear rates compatible with agroalimentary, pharmaceutical cosmetic applications. Three kinds were studied: one a high concentration primary emulsion, not viscosified in external phase; gelified synthetic polymer (Carbopol 974P((R))); other thickened chemically modified cellulose (hydroxypropylcellulose). The results this study show influence composition fragmentation release as function rate. Despite these differences behavior respect to rate, each emulsion fits Taylor's theoretical framework, indicating that bursting mechanisms globules are same whatever emulsions.
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Manmohan Singh, Catarina Hioe, Howard Qiu, Xuan-Mao Li, Chang Yi Wang, Wayne Koff, Timothy Zamb, Douglas F. Nixon, CTL induction using synthetic peptides delivered in emulsions— critical role of the formulation procedure Vaccine. ,vol. 15, pp. 1773- 1778 ,(1997) , 10.1016/S0264-410X(97)00109-6
K. S. Chang, W. L. Olbricht, Experimental studies of the deformation and breakup of a synthetic capsule in steady and unsteady simple shear flow Journal of Fluid Mechanics. ,vol. 250, pp. 609- 633 ,(1993) , 10.1017/S0022112093001582
T. G. Mason, J. Bibette, Emulsification in Viscoelastic Media. Physical Review Letters. ,vol. 77, pp. 3481- 3484 ,(1996) , 10.1103/PHYSREVLETT.77.3481
S. Raynal, J.L. Grossiord, M. Seiller, D. Clausse, A topical W/O/W multiple emulsion containing several active substances : formulation, characterization and study of release Journal of Controlled Release. ,vol. 26, pp. 129- 140 ,(1993) , 10.1016/0168-3659(93)90112-I
Takayuki Ohwaki, Ryouichi Machida, Hiroshi Ozawa, Yoshiaki Kawashima, Tomoaki Hino, Hirofumi Takeuchi, Toshiyuki Niwa, Improvement of the stability of water-in-oil-in-water multiple emulsions by the addition of surfactants in the internal aqueous phase of the emulsions International Journal of Pharmaceutics. ,vol. 93, pp. 61- 74 ,(1993) , 10.1016/0378-5173(93)90164-B
Bruno de Cindio, Gianni Grasso, Domenico Cacace, Water-in-oil-in-water double emulsions for food applications: yield analysis and rheological properties Food Hydrocolloids. ,vol. 4, pp. 339- 353 ,(1991) , 10.1016/S0268-005X(09)80130-6
Eric Dickinson, Jane Evison, Richard K. Owusu, Preparation of fine protein-stabilized water-in-oil-in-water emulsions Food Hydrocolloids. ,vol. 5, pp. 481- 485 ,(1991) , 10.1016/S0268-005X(09)80106-9
V. Muguet, M. Seiller, G. Barratt, N. Hebel, J. P. Marty, J. L. Grossiord, Influence of the fragmentation of multiple globules on the rheological properties of W/O/W multiple emulsions Journal of Rheology. ,vol. 44, pp. 379- 395 ,(2000) , 10.1122/1.551090
F.D Rumscheidt, S.G Mason, Particle motions in sheared suspensions XII. Deformation and burst of fluid drops in shear and hyperbolic flow Journal of Colloid Science. ,vol. 16, pp. 238- 261 ,(1961) , 10.1016/0095-8522(61)90003-4
Eric Dickinson, Michael I. Goller, David J. Wedlock, Creaming and rheology of emulsions containing polysaccharide and non-ionic or anionic surfactants Colloids and Surfaces A: Physicochemical and Engineering Aspects. ,vol. 75, pp. 195- 201 ,(1993) , 10.1016/0927-7757(93)80430-M