Molecular features of macrophage activation.

摘要: Cellular activation is mainly defined as the response of a cell to exogenous signals eventually leading changes in protein expression and cellular function. Originally, macrophage was associated with phagocytic Later other effector functions such cytokine secretion, upregulation surface receptors came into focus. For while classified being either pro-inflammatory or anti-inflammatory certain signal transduction pathways were these two conditions. Most recent findings on transcriptional epigenetic level, however, suggest that molecular features are significantly more complex. Here, we will introduce novel integrative model activation. Albeit recognizing cannot be reduced nuclear processes, focus this review most concerning regulation Understanding complexity central regulatory mechanisms nucleus form foundation for deciphering all different