Glucose tolerance and ancestral genetic admixture in six semitraditional Pacific populations.

摘要: Population-based data on 1,842 subjects from six semitraditional Pacific communities, collected in the years 1978-1983, have been compared order to examine hypotheses that differences distribution of plasma glucose concentration between populations are some extent genetically determined, and non-Austronesian (NAN) Melanesians relatively resistant intolerance. Semitraditional communities were chosen for study so comparison would be minimally confounded by either known or as yet undetermined environmental factors associated with nontraditional living, effects which may vary populations. The samples also selected provide a gradient proportional NAN AN admixture. They drawn following regions: highlands Papua New Guinea, Caledonia, Fiji, Wallis Islands, Western Samoa, Kiribati (formerly Gilbert Islands). Guinea highlanders, entirely ancestry, regarded baseline population. A increasing mean 2-hr was observed across persisted populations, after controlling age obesity. Variations diet, physical activity, degree sociocultural modernization not considered sufficient consistent explanation these findings they therefore lend tentative support hypothesis genetic component variability tolerance. relationship population estimates tolerance distance Melanesian sample examined. With notable exception there evidence linear correlation two parameters.