Predictions of cognitive detriments from galactic cosmic ray exposures to astronauts on exploration missions.

摘要: Abstract For the first-time we report on predictions cognitive detriments from galactic cosmic ray (GCR) exposures long-duration space missions outside protection of Earth's magnetosphere and solid body shielding. Estimates are based a relative risk (RR) model fluence response for proton heavy ion in rodent studies using widely used novel object recognition (NOR) test, which estimates or memory. Our recent meta-analysis showed that linear linear-quadratic dose models were not accurate, while exponential increasing particle track structure provided good descriptions data doses up to 1 Gy. Using detailed GCR environment transport shielding tissue, predict excess (ERR) NOR several long-term mission scenarios. Predictions suggest ERR 0.1 1-year lunar surface missions, about ERR~0.1 1000 day Mars average solar cycle conditions. We discuss possible implications these levels performance other neurological challenges such as Alzheimer's disease (AD), Parkinson's (PD) traumatic brain injury (TBI). Comparisons small but potentially clinically significant