Insulin stimulates turnover of phosphatidylcholine in rat adipocytes.
作者： S. Lance Macaulay , Richard G. Larkins
DOI: 10.1007/BF00931600
关键词:
摘要: The present study investigated the effect of insulin on phosphatidylcholine turnover in rat adipocytes labelled to equilibrium with [14C]-choline. Insulin induced a rapid this major phospholipid that was maximal by 1 min and transient nature. Following stimulation cells at maximally effective concentration (7 nM), 4–6% decrease percentage total cellular choline associated observed. This reflected significant increase phosphorylcholine, which together diacylglycerol are phospholipase C cleavage products phosphatidylcholine. These effects were observed over physiological range concentrations. No any other or metabolite (sphingomyelin, lysophophatidylcholine, glycerophosphocholine choline) seen. results suggest stimulates C-mediated adipocytes. nature suggests potential role signal transduction.
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