Structural and Biochemical Studies of Human 4-hydroxy-2-oxoglutarate Aldolase: Implications for Hydroxyproline Metabolism in Primary Hyperoxaluria
作者： Travis J. Riedel , Lynnette C. Johnson , John Knight , Roy R. Hantgan , Ross P. Holmes
DOI: 10.1371/JOURNAL.PONE.0026021
关键词:
摘要: Background 4-hydroxy-2-oxoglutarate (HOG) aldolase is a unique enzyme in the hydroxyproline degradation pathway catalyzing cleavage of HOG to pyruvate and glyoxylate. Mutations this are believed be associated with excessive production oxalate primary hyperoxaluria type 3 (PH3), although no experimental data available support hypothesis. Moreover, identity, oligomeric state, enzymatic activity, crystal structure human HOGA have not been experimentally determined.
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