Helical Flow Component of Left Ventricular Assist Devices (LVADs) Outflow Improves Aortic Hemodynamic States
作者： Qi Zhang , Bin Gao , Yu Chang
DOI: 10.12659/MSM.905940
关键词:
摘要: BACKGROUND Although LVADs are confirmed to have strong effects on aortic hemodynamics, the precise mechanisms of helical flow component LVAD outflow still unclear. MATERIAL AND METHODS To clarify these effects, 3 cases - normal case, flat and realistic case were designed studied by using CFD approach. The denoted aorta without support, represented with cannula. Similarly, included model, model cannula, LVAD. velocity vector, blood streamline, distribution wall shear stress (WSS), local normalized helicity (LNH) calculated. RESULTS results showed that significantly improved hemodynamics. Compared eliminated vortex near outer transport (normal 0.1 m/s vs. 0.14 0.30 m/s) at descending aorta. Moreover, was even WSS, reduce peak value WSS 0.92 Pa 7.39 5.2Pa), maintain a more orderly direction. CONCLUSIONS has significant advantages for improving hemodynamic stability. Our study provides novel insights into optimization.
medscitechnol.com参考文章(31)
Maria Vittoria Caruso, Vera Gramigna, Michele Rossi, Giuseppe Filiberto Serraino, Attilio Renzulli, Gionata Fragomeni, A computational fluid dynamics comparison between different outflow graft anastomosis locations of Left Ventricular Assist Device (LVAD) in a patient‐specific aortic model International Journal for Numerical Methods in Biomedical Engineering. ,vol. 31, ,(2015) , 10.1002/CNM.2700
Christof Karmonik, Sasan Partovi, Bastian Schmack, Alexander Weymann, Matthias Loebe, George P. Noon, Patrizia Piontek, Matthias Karck, Alan B. Lumsden, Arjang Ruhparwar, Comparison of hemodynamics in the ascending aorta between pulsatile and continuous flow left ventricular assist devices using computational fluid dynamics based on computed tomography images. Artificial Organs. ,vol. 38, pp. 142- 148 ,(2014) , 10.1111/AOR.12132
Véronique Peiffer, Spencer J. Sherwin, Peter D. Weinberg, Computation in the rabbit aorta of a new metric - the transverse wall shear stress - to quantify the multidirectional character of disturbed blood flow. Journal of Biomechanics. ,vol. 46, pp. 2651- 2658 ,(2013) , 10.1016/J.JBIOMECH.2013.08.003
Yu Chang, Bin Gao, Modeling and identification of an intra-aorta pump. Asaio Journal. ,vol. 56, pp. 504- 509 ,(2010) , 10.1097/MAT.0B013E3181EFFF2D
Tal Hasin, Yasushi Matsuzawa, Raviteja R. Guddeti, Tatsuo Aoki, Taek-Geun Kwon, Sarah Schettle, Ryan J. Lennon, Ramesh G. Chokka, Amir Lerman, Sudhir S. Kushwaha, Attenuation in Peripheral Endothelial Function After Continuous Flow Left Ventricular Assist Device Therapy Is Associated With Cardiovascular Adverse Events Circulation. ,vol. 79, pp. 770- 777 ,(2015) , 10.1253/CIRCJ.CJ-14-1079
L J Frazin, G Lanza, M Vonesh, F Khasho, C Spitzzeri, S McGee, D Mehlman, K B Chandran, J Talano, D McPherson, Functional chiral asymmetry in descending thoracic aorta. Circulation. ,vol. 82, pp. 1985- 1994 ,(1990) , 10.1161/01.CIR.82.6.1985
Joseph S. Uzarski, Edward W. Scott, Peter S. McFetridge, Adaptation of Endothelial Cells to Physiologically-Modeled, Variable Shear Stress PLoS ONE. ,vol. 8, pp. e57004- ,(2013) , 10.1371/JOURNAL.PONE.0057004
P J Kilner, G Z Yang, R H Mohiaddin, D N Firmin, D B Longmore, Helical and retrograde secondary flow patterns in the aortic arch studied by three-directional magnetic resonance velocity mapping. Circulation. ,vol. 88, pp. 2235- 2247 ,(1993) , 10.1161/01.CIR.88.5.2235
Christof Karmonik, Sasan Partovi, Matthias Loebe, Bastian Schmack, Ali Ghodsizad, Mark R. Robbin, George P. Noon, Klaus Kallenbach, Matthias Karck, Mark G. Davies, Alan B. Lumsden, Arjang Ruhparwar, Influence of LVAD cannula outflow tract location on hemodynamics in the ascending aorta: A patient-specific computational fluid dynamics approach Asaio Journal. ,vol. 58, pp. 562- 567 ,(2012) , 10.1097/MAT.0B013E31826D6232
Lee J. Frazin, Michael J. Vonesh, Krishnan B. Chandran, Tanya Shipkowitz, Adel S. Yaacoub, David D. McPherson, Confirmation and initial documentation of thoracic and abdominal aortic helical flow : An ultrasound study Asaio Journal. ,vol. 42, pp. 951- 956 ,(1996) , 10.1097/00002480-199642060-00006