Multiple Sclerosis and the Blood-Central Nervous System Barrier

摘要: The central nervous system (CNS) is isolated from the blood by a physical barrier that contains efflux transporters and catabolic enzymes. This blood-CNS (BCNSB) plays pivotal role in pathophysiology of multiple sclerosis (MS). It binds anchors activated leukocytes to permit their movement across BCNSB into CNS. Once there, these immune cells target particular self-epitopes initiate cascade neuroinflammation, which leads breakdown formation perivascular plaques, one hallmarks MS. Immunomodulatory drugs for MS are either biologics or small molecules, with only latter having capacity cross thus have propensity cause CNS side effects. However, penetration desirable feature molecular targets within These nabiximols dalfampridine, cannabinoid receptors potassium channels, respectively. Vascular cell adhesion molecule-1, present on endothelial BCNSB, also serves as drug discovery since it interacts α4-β1-integrin leucocytes. natalizumab, humanized monoclonal antibody against α4-β1-integrin, blocks this interaction reduces paper further elaborates pharmacotherapy