Breast and ovarian cancer incidence after infertility and in vitro fertilisation

摘要: Concern has been expressed that exposure to fertility drugs might be associated with a risk of ovarian cancer. We have examined the incidence breast and cancer in cohort 10,358 women referred for in-vitro fertilisation (IVF) treatment Victoria, Australia, between 1978 1992. The "exposed" group (n = 5564) had stimulation induce multiple folliculogenesis "unexposed" 4794) IVF but were untreated or "natural cycle" without stimulation. Duration follow-up ranged from 1 15 years. Cases determined by record linkage data population-based registries. 34 cases invasive 6 observed. A comparison expected numbers, derived applying age-standardised general population rates gave standardised ratios (SIR) 0.89 (95% CI 0.55-1.46) exposed 0.98 (0.62-1.56) unexposed group, SIRs 1.70 (0.55-5.27) 1.62 (0.52-5.02), respectively. Rates all cancers not significantly different rates. relative (RR) cancer, adjusted age infertility type, was, treated compared 1.11 0.56-2.20) 1.45 (0.28-7.55) body uterus was increased groups combined (SIR 2.84 [1.18-6.81]). Women unexplained infertility, independent exposure, risks (RR 19.19 [2.23-165.0]) 6.34 [1.06-38.0]) known causes infertility. This relatively short-term suggests is an Although there no after small number limits conclusions can drawn. Longer-term large cohorts who programmes will necessary.