Salidroside Inhibits HMGB1 Acetylation and Release through Upregulation of SirT1 during Inflammation
作者： Zhilin Qi , Yao Zhang , Shimei Qi , Liefeng Ling , Lin Gui
DOI: 10.1155/2017/9821543
关键词:
摘要: HMGB1, a highly conserved nonhistone DNA-binding protein, plays an important role in inflammatory diseases. Once released to the extracellular space, HMGB1 acts as proinflammatory cytokine that triggers reaction. Our previous study showed salidroside exerts anti-inflammatory effect via inhibiting JAK2-STAT3 signalling pathway. However, whether inhibits release of is still unclear. In this study, we aim effects on and then investigate potential molecular mechanisms. experimental rat model sepsis caused by CLP, administration significantly attenuated lung injury reduced serum level. RAW264.7 cells, investigated LPS-induced explored underlying We found inhibited release, inhibitory was correlated with acetylation levels. Mechanismly, through AMPK-SirT1 addition, SirT1 overexpression nucleocytoplasmic translocation. Furthermore, shRNA plasmid-transfected treatment enhanced expression LPS-activated Collectively, these results demonstrated might reduce pathway suppress
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