Suppression of tumor promotion by inhibitors of poly(ADP)ribose formation.

摘要: Tumor promoters, such as phorbol esters or hormones, cause many biological effects which may contribute to the expression of cancer. The mechanism cancer have a common theme. One method learning about this is identification chemicals that interfere with tumor development. That there actually theme between very different substances, inflammatory skin promoters and estradiol causing breast cancer, was shown by fact both cancers are suppressed same agents, e.g., protease inhibitors retinoids. In addition breast, suppress colon, bladder, liver cancers. substances crossed over in suppressing varieties were found inhibit oxygen radical formation promoter-activated neutrophils ras oncogene NIH 3T3 cells. Poly(ADP)ri— bose polymerase (PADPR polymerase) serve connecting link radicals its activation expression. PADPR inhibited retinoids, antioxidants, some inhibitors. Benzamide, an inhibitor polymerase, also chymotrypsin suppresses neutrophils. inhibition causes expulsion oncogenes from cells at definite times after transfection. Further work required find what contributions promotion suppression