Omega 3 fatty acid for the prevention of dementia.

摘要: BACKGROUND: Accruing evidence from observational and epidemiological studies suggests an inverse relationship between dietary intake of omega 3 polyunsaturated fatty acid (PUFA) risk dementia. Postulated mechanisms that might qualify PUFA as interventional target for the primary prevention dementia include its anti-atherogenic, anti-inflammatory, anti-oxidant, anti-amyloid neuroprotective properties. OBJECTIVES: To review supplementation prevents cognitive impairment in cognitively intact elderly persons. SEARCH STRATEGY: The Cochrane Dementia Cognitive Improvement Group's (CDCIG) Specialized register, MEDLINE, EMBASE,CINAHL PsycINFO, AMED AND CENTRAL several ongoing trials databases were searched on 5 6 October 2005. CDCIG Register is updated regularly contains records all major medical many databases. SELECTION CRITERIA: In order to be selected, needed randomized, placebo-controlled, doubled blinded, minimum study duration months, involved persons aged 60 years above without pre-existing at onset, employed endpoints. DATA COLLECTION ANALYSIS: Reviewers, working independently, select, quality assess extract relevant data where appropriate possible. comparing intervention with placebo, pooled odds ratios or weighted mean differences standardized difference estimated. MAIN RESULTS: There no randomized found search met selection criteria. Results two clinical are expected 2008. AUTHORS' CONCLUSIONS: a growing body biological, protective effect against However, until become available analysis, there good support use supplemental