Adherence to biologic therapies and associated factors in rheumatoid arthritis, spondyloarthritis and psoriatic arthritis: a systematic literature review.

摘要: Objectives To analyse the evidence on adherence to biologic therapies in rheumatoid arthris (RA), spondyloarthritis (SpA), and psoriatic arthritis (PsA). Methods Systematic review of studies retrieved by a sensitive search strategy MEDLINE database (1961 through March 2012). be selected, had include patients with RA, SpA, or PsA, treatment intravenous subcutaneous therapies, report measures adherence. By design, only randomised controlled trials (RCT) high quality cohort control group were selected. Results A total 24 included, which 12 reported results from national local registers, 9 retrospective studies, 2 prospective one was an RCT. Patients included mostly women diagnosis RA SpA and, less frequently, PsA. There great variability definition adherence, measurement methods, associated factors analysed. In general, etanercept superior that other biologics, utilised. The main predictive - age, sex, comorbidity, baseline clinical condition, previous concomitant use DMARDs, anti-TNF monotherapy combination MTX produced diverse, even divergent across studies. Conclusions is wide related concept its measurement, reflecting complexity phenomenon. order draw more consistent conclusions about relative value persistence biological therapy, larger better selection variables analysis interactions are needed.