Dietary lyophilized colostrum alters distribution of goblet cells and the intestinal epithelium of Piaractus mesopotamicus

摘要: Abstract The intestinal epithelium is responsible for the first line of defense, directly influenced by bioactive, dietary molecules. lyophilized bovine colostrum (LBC) a nutraceutical and surrogate protein source farmed fish. This study aimed at evaluating distribution goblet cells morphometric changes in juvenile, neotropic Characin pacu Piaractus mesopotamicus fed diets containing 0%, 10% or 20% LBC either 30 60 days. Muscle layer thickness (MLT); partial volume absorptive mucosa (Vv); number acidic neutral mucins subtypes – sialomucin sulphomucin, were studied three segments (S1, S2, S3 rectum). Fish had enlarged MLT 60 days S2 segment, increased sulphomucin S1, as well total Juveniles reduced mucin, mucin was higher juveniles than those 0% Dietary development muscle juvenile pacu, improving capacity nutrient macromolecules absorption segment. presence unidentified substances from determined reaction with subsequent production mucin. Statement Relevance Alternatives fish nutrition are placed annually world market expectation getting quick performance minimum cost. As an alternative animal food, may be innovative when added bioactive peptides such neotropical species. lyophilization process preserves quality unique features colostrum, like antioxidant, immunological antimicrobial proprieties. Additionally, present work contributes to better understanding basic histology species, that still demands studies about enteric physiology. sialomucins, sulphomucins omnivorous contribute evaluation nutritional alternatives enable greater efficiency national level. In this context, manuscript complementary others already published papers, which includes feasibility using fish, consequences biological active molecules, IGF-1, on morphology.