Possibility of Drug-Drug Interaction in Prescription Dispensed by Community and Hospital Pharmacy

摘要: Objective: To analyze the use of all subsidized prescription drugs including their of drug combination generally accepted as carrying a risk severe interactions. Methodology: In cross sectional study, we analyzed prescriptions (n = 1014) involving two or more dispensed to population (age range 4-85 years) from all pharmacies, clinics and hospitals. Data were stratified by age sex, and frequency common interacting drugs. Potential drug interactions were classified according clinical relevance significance severity (types A: major, B: moderate, C: minor) documented evidence 1, 2, 3, and 4). Result Discussion: The growing pharmacological agents means that drug are increasing interest for public health. Monitoring of potential may improve quality prescribing and dispensing, it might form basis education focused on appropriate prescribing. To make manifestation adverse interaction subside, management strategies must be exercised if two have be taken with each other, involving: adjusting dose object drug; spacing dosing times avoid interaction. pharmacist, along the prescriber has duty ensure that patients aware side effects suitable course action they should take. Conclusion: It is unrealistic expect clinicians memorize thousands drug-drug interactions significance, especially considering rate of introduction novel escalating appreciation the importance pharmacogenomics. Reliable regularly updated decision support systems information technology necessary help avert dangerous drug combinations.