Using residential histories in case-control analysis of lung cancer and mountaintop removal coal mining in Central Appalachia.
作者： W.J. Christian , C.J. Walker , B. Huang , J.E. Levy , E. Durbin
DOI: 10.1016/J.SSTE.2020.100364
关键词:
摘要: Population-based ecological and cross-sectional studies have observed high risk for several cancers in areas of Central Appalachia where mountaintop removal coal mines operate. Case-control could provide stronger evidence such relationships, but misclassification exposure is likely when based on current residence, since individuals inhabited residences with varying environmental exposures over many years. To address this, we used residential histories enrolled a previous case-control study lung cancer to assess proximity mining 30-year period, using both survey data proprietary from LexisNexis, Inc. Supplementing the LexisNexis improved precision completeness geographic coordinates. Final logistic regression models revealed higher odds among cases. These findings suggest that living close sites increase cancer, after adjusting other relevant factors.
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