How to re-energise old mitochondria without shooting yourself in the foot.

摘要: In old humans and pathologies associated with mitochondrial mutations, deletions in DNA have been failing function. Investigations reported where treatment a number of micronutrients, such as coenzyme Q10, used to re-energise tissues. Bioenergy changes ageing Drosophila observed which indicate similar function age. Reserves carbohydrate fat fall food intake rises. Biochemical include falling enzymes. Mitochondrial contains increased amounts sequences corresponding deletions. Both Q10 nicotinamide large doses successfully reversed bioenergy aged Drosophila. However, only was able reduce short term mortality increase life span, whereas reduced span. Production reactive oxygen species (ROS) treated flies, ROS production. It is suggested that production may account for these longevity differences. Large two micronutrients successful reversing the age-associated deficit This response clinical reports re-energising tissues damage has observed. this work highlights danger some efficacy be limited by