Apoptosis and the target genes of microRNA-21.

摘要: MicroRNA-21 (miR-21) is frequently up-regulated in cancer and the majority of its reported targets are tumor suppressors. Through functional suppression, miR-21 implicated practically every walk oncogenic life: promotion cell proliferation, invasion metastasis, genome instability mutation, inflammation, replicative immortalization, abnormal metabolism, angiogenesis, evading apoptosis, immune destruction, growth In particular, strongly involved apoptosis. this article, we reviewed experimentally validated found that two thirds linked to intrinsic and/or extrinsic pathways cellular This suggests an Oncogene which plays a key role resisting programmed death cells targeting apoptosis viable therapeutic option against cancers expressing miR-21.