Oxaliplatin-induced Peripheral Neuropathy in South Indian Cancer Patients: A Prospective Study in Digestive Tract Cancer Patients.

摘要: Purpose: The aim of the current study is to report our prospective experience on prevalence oxaliplatin-induced peripheral neuropathy (OXAIPN) in patients with digestive tract cancers treated oxaliplatin-based combination therapy. Materials and Methods: A total 219 scheduled be therapy were prospectively examined at baseline follow-up during between November 2014 December 2016. incidence acute OXAIPN was measured using a descriptive questionnaire (yes/no question) based sum number symptoms present NCI-CTCAE version 4.03 applied clinically grade severity chronic OXAIPN. Results: Acute found 108 (49.3%) 127 (58%) patients, respectively. Out 11 symptoms, vast majority manifested cold-induced pharyngolaryngeal (63.8%) dysesthesias or perioral (61.1%) paresthesias. Development predictive subsequent development ( P = 0.0001). All received median cumulative dose 780 mg/m 2 (range: 130–1040 ). There significant correlation who incidences ≤780 51/120 (42.5%) >780 76/99 (76.7%) Conclusion: results demonstrate that receive chemotherapy will manifest may contribute repeated courses drug administration.