Natural history of chronic hepatitis C

摘要: Much controversy surrounds the issue of natural history hepatitis C virus (HCV) infection. Many authorities view disease as inexorably progressive with a high probability advancing over time to cirrhosis and occasionally hepatocellular carcinoma (HCC) and, therefore, likely be responsible for causing death. Others regard chronic having variable outcome, majority infected persons not dying from disease, but more comorbid conditions that so often accompany infection by this agent, or common medical conditions. Disagreements probably derive manner conduct study populations studied. Efforts determine are handicapped primary characteristics namely its onset rarely is recognized course prolonged exceedingly. Thus, different outcomes have come retrospective rather than prospective studies, both concluded at least 20% chronically adults develop within 20 years. More recent studies used retrospective/prospective approach, focusing largely on young individuals, produced results. Among these people, particularly women, spontaneous resolution viral previously thought has been identified in 5% fewer them. The major failing all groups studied, old, exceeded first 2 decades, outcome beyond known, other through modeling. Several host-related extraneous factors affect history.