Resistance of uropathogens in symptomatic urinary tract infections in León, Nicaragua

摘要: Management of urinary tract infections (UTI) in Central America and especially Nicaragua, is complicated by the lack knowledge about antibiotic resistance uropathogens. We conducted a prevalence study to gain more insight into aetiology, bacterial risk factors for symptomatic UTI region Leon, Nicaragua. In 2002, all consecutive patients with symptoms pyuria >/=10 WBC/hpf were admitted study. Positive cultures from midstream urine specimens defined as >/=10(5) cfu/ml single uropathogen. Susceptibility tests performed disc diffusion using Kirby-Bauer method broth microdilution National Committee Clinical Laboratory Standards criteria both Leon reference laboratory Utrecht. A positive culture was present 62 208 subjects (30%). Escherichia coli (56%), Klebsiella spp. (18%) Enterobacter (11%) most frequent pathogens isolated. Presence cystocele, incontinence increasing age UTI. E. least resistant ceftriaxone, amikacin nitrofurantoin (>90% susceptible). observed high rates amoxicillin (82%, MIC(90) 128 mg/l), trimethoprim-sulphamethoxazole (TMP-SMX) (64%, 32 cephalothin (58%, MIC(90), ciprofloxacin (30%; amoxicillin/clavulanate (21%, 8 mg/l) gentamicin (12%, 2 mg/l). Our results suggests that community acquired uropathogens Nicaragua are highly many antimicrobial agents. The use amoxicillin, against needs be reconsidered. High quinolone among gives cause great concern.