Gut hormones in relation to body mass and torpor pattern changes during food restriction and re-feeding in the gray mouse lemur

作者: Sylvain Giroud , Martine Perret , Yvon Le Maho , Iman Momken , Caroline Gilbert

DOI: 10.1007/S00360-008-0294-4

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摘要: Potential implications of gut hormones in body mass and torpor behavioral pattern changes induced by an incremental (40 80%) calorie restriction (CR) long-days (LD, summer) short-days (SD, winter) were investigated gray mouse lemurs. Only 80% food-deprived LD SD animals showed a continuous loss resulting 10 15% reduction, respectively. Ghrelin levels all groups increased 2.6-fold on average remained high after re-feeding while peptide YY (PYY) 3.8-fold only under CR. In the re-fed group, was positively associated with ghrelin negatively PYY, no correlations noted animals. Plasma glucagon-like peptide-1 (GLP-1) 2.9-fold food-restricted lemurs minimal temperature. No significant reported These results suggest that ghrelin, PYY GLP-1 may be related to pre-wintering fattening mechanisms modulation expression, Such observation clearly warrants further investigations, but it opens interesting area research regulation.

参考文章(65)
Julian G Mercer, Regulation of appetite and body weight in seasonal mammals Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology. ,vol. 119, pp. 295- 303 ,(1998) , 10.1016/S0742-8413(98)00018-8
F. Geiser, G. Heldmaier, The impact of dietary fats, photoperiod, temperature and season on morphological variables, torpor patterns, and brown adipose tissue fatty acid composition of hamsters, Phodopus sungorus Journal of Comparative Physiology B-biochemical Systemic and Environmental Physiology. ,vol. 165, pp. 406- 415 ,(1995) , 10.1007/BF00387311
Birgitte Sloth, Jens Juul Holst, Anne Flint, Nikolaj Ture Gregersen, Arne Astrup, Effects of PYY1-36 and PYY3-36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects. American Journal of Physiology-endocrinology and Metabolism. ,vol. 292, ,(2007) , 10.1152/AJPENDO.00450.2006
Peter J. Morgan, Julian G. Mercer, The regulation of body weight: lessons from the seasonal animal. Proceedings of the Nutrition Society. ,vol. 60, pp. 127- 134 ,(2001) , 10.1079/PNS200060
A Katsuki, H Urakawa, EC Gabazza, S Murashima, K Nakatani, K Togashi, Y Yano, Y Adachi, Y Sumida, Circulating levels of active ghrelin is associated with abdominal adiposity, hyperinsulinemia and insulin resistance in patients with type 2 diabetes mellitus. European Journal of Endocrinology. ,vol. 151, pp. 573- 577 ,(2004) , 10.1530/EJE.0.1510573
P. C. Yannielli, P. C. Molyneux, M. E. Harrington, D. A. Golombek, Ghrelin effects on the circadian system of mice. The Journal of Neuroscience. ,vol. 27, pp. 2890- 2895 ,(2007) , 10.1523/JNEUROSCI.3913-06.2007
Suguru Nakamura, Glucose activates H+-ATPase in kidney epithelial cells American Journal of Physiology-cell Physiology. ,vol. 287, ,(2004) , 10.1152/AJPCELL.00469.2003
Fritz Geiser, The effect of unsaturated and saturated dietary lipids on the pattern of daily torpor and the fatty acid composition of tissues and membranes of the deer mouse Peromyscus maniculatus. Journal of Comparative Physiology B-biochemical Systemic and Environmental Physiology. ,vol. 161, pp. 590- 597 ,(1991) , 10.1007/BF00260749