Primary rectal choriocarcinoma associated with rectal adenocarcinoma in a woman with a history of ulcerative colitis: Case report.

摘要: Abstract Introduction Primary rectal choriocarcinoma is an extremely rare malignancy. The association of these neoplasms in patients with inflammatory bowel disease (IBD) has not been reported. Presentation case A 34-year-old female history Ulcerative Colitis (UC) gave birth to a male fetus. She had postpartum bleeding and high level beta-human chorionic gonadotropin (βhCG) was detected. Although initial investigations failed confirm molar pregnancy, abnormal uterine βhCG necessitate chemotherapy administration. did respond sessions accordingly. Meanwhile, the patient experienced rectorrhagia colonoscopy revealed firm submucosal polypoid lesion 8–10 cm from anal verge. multidisciplinary team candidate for total proctocolectomy ileal pouch anastomosis. postoperative course uneventful dropped but it showed rising pattern follow ups. Chemotherapy planned there suitable response. Unfortunately, passed away 20 months after diagnosis. Discussion Pathology report indicated coexistence moderately differentiated tubular adenocarcinoma choriocarcinoma. We assume previous UC might have put her at higher susceptibility develop carcinoma this poorly led Considering fact that most cases colorectal choriocarcinoma, choriocarcinomatous differentiation found alongside colonic made dedifferentiation theory be acceptable explanation. Conclusion colon rectum setting IBD may become so dedifferentiated gain some characteristics germ cell tumors.