Epidemiology, Screening, Pathology and Pathogenesis

摘要: Prostate cancer (PCa) is the most common affecting men in Western world, and a less prominent cause of death. Because PCa often grows so slowly that die other causes before disease becomes clinically advanced. specific antigen (PSA) testing revolutionized screening epidemiologic evidence supports role PSA stage grade migration prostate cancer, but to date for its changing mortality patterns more equivocal. As result, has been controversial issue because decisions were made about adopting absence efficacy data from randomized trials. There currently no introducing widespread population-based programmes early detection all men. Adenocarcinoma accounts vast majority PCa. It multifocal than 85 % cases. The Gleason score commonly used system grading factors determine risk developing clinical are not well known, although three well-established have identified: increasing age, ethnic origin, heredity. Exogenous affect progression so-called latent In last 20 years, may be caused by multiple genes, possibly interacting with endocrine environmental factors, continued grow.