Effectiveness of protecting the myocardium against ischemia with a normothermic cardioplegic solution and creatine phosphate

作者: I. B. Zbarskii , V. A. Shlyakhovenko , E. N. Zhmareva , I. A. Brodskaya , A. V. Peskin

DOI: 10.1007/BF00806630

关键词:

摘要: The protective effects of cardioplegic solutions (CS) containing creatine phosphate (CP) were studied in a rat heart model cardiopulmonary bypass and ischemic cardiac arrest. Isolated hearts subjected to 3-minute coronary infusion with CS CP normothermic (37 degrees C) hypothermic (4-6 regimes. In the normothermia group, postischemic functional recovery was 70-75% preischemic control value, while cellular ATP content reduced but insignificantly. By contrast, hypothermia markedly depressed, tissue high-energy being appreciably lowered. data obtained confirm high efficacy CP-containing administered under conditions.

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