Depressive disorders in the elderly and dementia: an update
作者： Natália S. Dias , Izabela G. Barbosa , Weihong Kuang , Antonio L. Teixeira
DOI: 10.1590/1980-57642020DN14-010001
关键词:
摘要: The relationship between depressive disorders in the elderly and dementia, particularly Alzheimer's disease (AD), is highly complex. While nature of this still a matter debate, differential diagnosis treatment remain great clinical challenge. We review recent findings on conundrum AD. There biological continuum - or at least subgroup them subjects with depression patients AD exhibit higher circulating levels pro-inflammatory molecules lower BDNF than matched controls, CSF Aβ42 can discriminate from elderly. role antidepressant as strategy to minimize risk remains be established.
sci-hub.st 参考文章(64)
I R Katz, J P Docherty, G S Alexopoulos, D Carpenter, C F Reynolds rd, The expert consensus guideline series. Pharmacotherapy of depressive disorders in older patients. Postgraduate Medicine. pp. 1- 86 ,(2001)
Rita Haapakoski, Julia Mathieu, Klaus P. Ebmeier, Harri Alenius, Mika Kivimäki, Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder Brain Behavior and Immunity. ,vol. 49, pp. 206- 215 ,(2015) , 10.1016/J.BBI.2015.06.001
Taylor Reis, Carlos Otavio Brandão, Evandro Silva Freire Coutinho, Eliasz Engelhardt, Jerson Laks, Cerebrospinal fluid biomarkers in Alzheimer's disease and geriatric depression: preliminary findings from Brazil. CNS Neuroscience & Therapeutics. ,vol. 18, pp. 524- 529 ,(2012) , 10.1111/J.1755-5949.2012.00311.X
Joakim Hertze, Lennart Minthon, Henrik Zetterberg, Eugeen Vanmechelen, Kaj Blennow, Oskar Hansson, Evaluation of CSF biomarkers as predictors of Alzheimer's disease: a clinical follow-up study of 4.7 years. Journal of Alzheimer's Disease. ,vol. 21, pp. 1119- 1128 ,(2010) , 10.3233/JAD-2010-100207
Sarah A. Hiles, Amanda L. Baker, Theo de Malmanche, John Attia, A meta-analysis of differences in IL-6 and IL-10 between people with and without depression: Exploring the causes of heterogeneity Brain Behavior and Immunity. ,vol. 26, pp. 1180- 1188 ,(2012) , 10.1016/J.BBI.2012.06.001
Isaac Schweitzer, Virginia Tuckwell, David Ames, John O'brien, Structural neuroimaging studies in late-life depression: a review. World Journal of Biological Psychiatry. ,vol. 2, pp. 83- 88 ,(2001) , 10.3109/15622970109027497
Cassiano L.S. Coelho, José Alexandre S. Crippa, Jair L.F. Santos, Ilana Pinsky, Marcos Zaleski, Raul Caetano, Ronaldo Laranjeira, Higher prevalence of major depressive symptoms in Brazilians aged 14 and older Revista Brasileira de Psiquiatria. ,vol. 35, pp. 142- 149 ,(2013) , 10.1590/1516-4446-2012-0875
John T. O'Brien, David Ames, Isaac Schweitzer, Peter Colman, Patricia Desmond, Brian Tress, Clinical and magnetic resonance imaging correlates of hypothalamic-pituitary-adrenal axis function in depression and Alzheimer's disease. British Journal of Psychiatry. ,vol. 168, pp. 679- 687 ,(1996) , 10.1192/BJP.168.6.679
Sharon L. Naismith, Louisa M. Norrie, Loren Mowszowski, Ian B. Hickie, The neurobiology of depression in later-life: Clinical, neuropsychological, neuroimaging and pathophysiological features Progress in Neurobiology. ,vol. 98, pp. 99- 143 ,(2012) , 10.1016/J.PNEUROBIO.2012.05.009
L L Herrmann, M Le Masurier, K P Ebmeier, White matter hyperintensities in late life depression: a systematic review Journal of Neurology, Neurosurgery, and Psychiatry. ,vol. 79, pp. 619- 624 ,(2007) , 10.1136/JNNP.2007.124651