Oxidative trifluoromethyl(thiol/selenol)ation of terminal alkynes: An overview

摘要: Abstract The development of mild, selective, and practical methods for the introduction fluorine atom fluorine-containing functional groups into organic molecules has received tremendous attention because many pharmaceuticals, agrochemicals, refrigerants, high performance materials (e.g., plastics, elastomers, membranes, textile finishes coatings) owe their important properties to presence atoms within structures. Trifluoromethyl (CF3), trifluoromethylthio (SCF3), trifluoromethylseleno (SeCF3) are among most popular in medicinal chemistry, since these considerably improve pharmacological activities molecule due lipophilicity electronegativity. Recent chemical approaches incorporation titled molecules, based upon direct trifluoromethyl(thiol/selenol)ation C H bonds without pre-functionalization starting materials. In this context, new strategies have been developed oxidative terminal alkynes, which allow highly economical rapid access biologically synthetically trifluoromethyl trifluoromethylthioalkynes, trifluoromethylselenoalkynes. This review intends summarize recent advances developments regarding alkynes with particular emphasis on mechanistic aspects reactions may serve as an inspiration further research appealing field.