Recent Developments on the Synthesis and Biological Activities of Fused Pyrimidinone Derivatives.
作者： Pule Seboletswe , Paul Awolade , Parvesh Singh , None
关键词:
摘要: Heterocyclic compounds constitute a unique class of organic endowed with wide range synthetic and pharmaceutical applications. Pyrimidinones their fused analogues have received focused attention in this regard, partly due to mimicry nucleobases which consequently forges interesting medicinal properties. Over the years, chemistry research community has experienced an upsurge articles describing exploration these scaffolds develop effective therapeutic agents. Several biological activities, including antimicrobial, antiviral, anticancer, antidiabetic, anti-inflammatory, anticonvulsive, antihistaminic, been well documented. This minireview presents compendium recent developments (2017-2020) on synthesis activities pyrimidinones. The goal is update chemists relevance pyrimidinones molecular architecture clinic-worthy drug candidates. A brief account structure-activity relationships (SAR) revealed from different assays also discussed.
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