Prickly pear (Opuntia sp.) pectin reverses low density lipoprotein receptor suppression induced by a hypercholesterolemic diet in guinea pigs.

摘要: The effects of prickly pear pectin on plasma LDL metabolism were investigated by feeding guinea pigs either a diet containing 15 g/100 g lard and 0.25 cholesterol (LC diet) or the LC in which cellulose was partially replaced (2.5 g) (LC-P diet). LC-P lowered concentrations 33% (P < 0.001). Low density lipoprotein composition modified intake pectin; relative percentages free esterified lower triglycerides higher from animals fed 0.05). Intake did not affect hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity; however, 46 64%, respectively. Hepatic apolipoprotein B/E receptor expression (Bmax) 60% 0.01). Similar to vitro data, receptor-mediated fractional catabolic rates 190% 0.05), whereas flux affected. Apolipoprotein pool size exhibited significant correlation (r = -0.52, P These data indicate that an increase is major metabolic response decreases concentrations.