[1,3]dioxolo[4,5-g]quinoline-6(5h)thione and [1,3]dioxolo[4,5-g][1,2,4]triazolo[1,5-a]quinoline derivatives as inhibitors of the late sv40 factor (lsf) for use in treating cancer
作者： Scott E. Schaus , Joshua A. Bishop , Ulla Hansen
DOI:
关键词:
摘要: The present invention relates generally to [l,3]dioxolo[4,5-g]quinoline-6(5H)thione and [1,3]dioxolo[4,5-g][1,2,4]triazolo[1,5-a]quinoline derivatives and/or compositions for use in inhibiting, preventing treating cancer, e.g. hepatocellular carcionoma (HCC). In some embodiments, the of small-molecule compounds inhibit, prevent treat expression transcription factor Late SV40 Factor (LSF) treatment HCC or other cancer types.
lens.org 参考文章(48)
Xiaolei Tan, Chung K. Chu, F.Douglas Boudinot, Development and optimization of anti-HIV nucleoside analogs and prodrugs: A review of their cellular pharmacology, structure-activity relationships and pharmacokinetics. Advanced Drug Delivery Reviews. ,vol. 39, pp. 117- 151 ,(1999) , 10.1016/S0169-409X(99)00023-X
Linda Mizen, George Burton, The Use of Esters as Prodrugs for Oral Delivery of β-Lactam Antibiotics Pharmaceutical biotechnology. ,vol. 11, pp. 345- 365 ,(2002) , 10.1007/0-306-47384-4_15
Jochanan Stenesh, Dictionary of biochemistry and molecular biology ,(1989)
Edward B. Roche, Design of biopharmaceutical properties through prodrugs and analogs The Academy. ,(1977)
Edward B. Roche, Bioreversible carriers in drug design : theory and application Pergamon Press. ,(1987)
Hans Bundgaard, Design of prodrugs Elsevier , Sole distributors for the USA and Canada, Elsevier Science Pub. Co.. ,(1985)
David Fleisher, Barbra H. Stewart, Gordon L. Amidon, [28] Design of prodrugs for improved gastrointestinal absorption by intestinal enzyme targeting Methods in Enzymology. ,vol. 112, pp. 360- 381 ,(1985) , 10.1016/S0076-6879(85)12030-6
Hans Bundgaard, C) Means to enhance penetration Advanced Drug Delivery Reviews. ,vol. 8, pp. 1- 38 ,(1992) , 10.1016/0169-409X(92)90014-H
Elise E. Drouin, Carol E. Schrader, Janet Stavnezer, Ulla Hansen, The Ubiquitously Expressed DNA-Binding Protein Late SV40 Factor Binds Ig Switch Regions and Represses Class Switching to IgA The Journal of Immunology. ,vol. 168, pp. 2847- 2856 ,(2002) , 10.4049/JIMMUNOL.168.6.2847
S.L. Swendeman, C. Spielholz, N.A. Jenkins, D.J. Gilbert, N.G. Copeland, M. Sheffery, Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2. Journal of Biological Chemistry. ,vol. 269, pp. 11663- 11671 ,(1994) , 10.1016/S0021-9258(19)78176-9