Age- and gender-related difference of ACE2 expression in rat lung

摘要: Epidemiologic data suggested that there was an obvious predominance of young adult patients with a slight female proneness in severe acute respiratory syndrome (SARS). The angiotensin-converting enzyme 2 (ACE2) very recently identified as functional receptor for SARS virus and is therefore prime target pathogenesis pharmacological intervention. Rats both genders at three distinct ages (young-adult, 3 months; middle-aged, 12 old, 24 months) were evaluated to determine the characteristic ACE2 expression lung effect aging gender on its expression. predominantly expressed alveolar epithelium, bronchiolar endothelium smooth muscle cells pulmonary vessels similar content, whereas no signal detected cells. dramatically reduced genders: young-adult vs. old P < 0.001 (by 78% male 67% female, respectively) middle-aged 71% rats 59% rats, respectively). decrease content relatively between groups 25% 18% Although gender-related difference groups, significantly higher than male. In conclusion, more elevated adults compared aged may contribute attacks this age group.