Apparatus and method for high-throughput preparation and spectroscopic classification and characterization of compositions

作者: Anthony V. Lemmo , Michael J. Cima , Javier P. Gonzalez-Zugasti , Alasdair Y. Johnson , Douglas A. Levinson

DOI:

关键词:

摘要: Systems and methods are described that allow the high-throughput preparation, processing, study of arrays samples, each which comprises at least one compound. Particular embodiments invention a large number experiments to be performed in parallel on samples comprised or more compounds milligram microgram quantities compounds. Other encompass devices for rapid screening results such experiments, as well rapidly determining whether not similarities exist among groups an array. preparation different forms (e.g., crystalline forms), discovery new old compounds, producing forms. Embodiments also determination how specific behave when exposed other chemicals environmental conditions.

参考文章(161)
Christian Elling, Lars Gerlach, Birgitte Holst Lange, Jan Pedersen, Thue Schwartz, Method of identifying ligands of biological target molecules ,(2000)
B B Beiswanger, V A Segreto, M E Mallatt, H J Pfeiffer, The prevalence and incidence of dental calculus in adults The Journal of clinical dentistry. ,vol. 1, pp. 55- 58 ,(1989)
Chul-Sung Kim, Roy W. Brown, Method for identification of unknown substances ,(1999)
Kenneth R. Morris, David Coates, G. Patrick Stahly, Barbara C. Stahly, Methods of screening for possible solid forms ,(2000)
Kin-Leong Pey, Kong Hean Lee, Harianto Wong, Eng Hua Lim, In-line process monitoring using micro-raman spectroscopy ,(1998)
Andrew Marshall, John Hodgson, DNA chips: an array of possibilities. Nature Biotechnology. ,vol. 16, pp. 27- 31 ,(1998) , 10.1038/NBT0198-27
Viktor Krchnak, Michael Lebl, Vit Pokorny, Apparatus and method for combinatorial chemistry synthesis ,(1998)
Kenneth P. J. Williams, Donald L. Gerrard, John E. Preedy, Diamond separation using raman scattering ,(1986)