Chapter 105 – Schizophrenia

摘要: Schizophrenia is a severe, chronic psychiatric illness characterized by delusions and hallucinations, negative ­symptoms, cognitive dysfunction that frequently leads to lifetime of impairment disability. appears be caused complicated interactions between heritable genetic risk factors range environmental exposures. Genome-wide association studies have identified common, rare, de novo structural mutations contribute the liability schizophrenia. Impairments in cortical subcortical circuitry, including ­disturbances multiple neurotransmitter systems, appear core components neurobiological basis Current treatments for schizophrenia include antipsychotic medications psychosocial ­interventions.