Rapid Bidirectional Effects of Insulin on Hypothalamic Noradrenergic and Serotoninergic Neuronal Activity in the Rat: Role in Glucose Homeostasis*
作者： G. A. SMYTHE , J. E. BRADSHAW , M. V. NICHOLSON , H. S. GRUNSTEIN , L. H. STORLIEN
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摘要: Glucose release from the liver is mediated by hypothalamic norepinephrine (NE) neuronal activity, but glucose itself (or a metabolite of it) exerts negative feedback effects on central NE activity. The aim present study was to investigate possible role for insulin in these homeostatic mechanisms. Computerized gas chromatographymass spectrometry used assess activities and serotonin [5-hydroxytryptamine (5-HT)] rats after acute (2 U/kg) administration. Medial basal activity assessed ratio 3,4-dihydroxyphenylethyleneglycol NE. suppressed (P < 0.005) 10 min administration rose again be significantly higher 0.05) than saline controls 30 at 45 post highly elevated. Hypothalamic 5-HT 5-hydroxyindoleacetic acid showed opposite those ...
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