Systematic ultrasound-guided saturation and template biopsy of the prostate: indications and advantages of extended sampling.

摘要: OBJECTIVES: Prostate biopsy (PB) is the gold standard for diagnosis of prostate cancer (PCa). However, optimal number cores remains debatable. We sought to compare contemporary (10-12 cores) vs. saturation (=18 schemes on initial as well repeat PB. METHODS: A non-systematic review literature was performed from 2000 through 2013. Studies highest evidence (randomized controlled trials, prospective non-randomized studies, and retrospective reports high quality) comparing vs PB were evaluated. Outcome measures overall PCa detection rate, rate insignificant PCa, procedure-associated morbidity. RESULTS: On PB, there growing that a scheme associated with higher compared one in men lower PSA levels ( 40 cc), or density values (<0.25 ng/ml/cc). these cut-offs are not uniform differ among studies. Detection rates do significant fashion between biopsies. likewise protocols. Estimates vary widely due differing definitions disease. appear be comparable patients only prior negative biopsy, while seems detect more cases two Very extensive sampling acute urinary retention, whereas other severe adverse events, such sepsis, occur frequently schemes. DISCUSSION: Current suggests ones larger prostates, PB. Since most data derived endpoints disease � especially show broad variations throughout must, thus, interpreted caution. Future trials should conducted extended templates newer techniques, image-guided sampling, order optimize diagnostic strategy.