Cytokine single nucleotide polymorphisms in Iranian patients with pulmonary tuberculosis.

摘要: Background. Several genes coding for different cytokines may affect host susceptibility to tuberculosis. Methods. In the present study, allele and genotype frequencies of a number polymorphic or cytokine receptors were investigated in Iranian patients with pulmonary tuberculosis (PTB). Results. From IL-1 cluster, positive, significant difference was found at position -889, where T/T over represented PTB (p = 0.01); increase IL1R PstI 1970 C/C genotype, C 0.01). A negative association codon 10 TGF-β, T allele, shown our (P<0.005). For TNF-α -238, we G/A positive G/G 0.0009). Significant associations -590 IL-4, 0.0007); also, T/C significantly increased (P<0.05). With IL-6 -174, G/C decreased Conclusion. Pro-inflammatory such as TGF-β seem be decreased, patients.