摘要: All methods for the generation of ions mass spectrometry described up to this point require analyte ionization be presented either directly under high vacuum (EI, CI, FI, FD) or contained in a sort solution from which are extracted into generated gas phase (FAB, LDI, MALDI). Even atmospheric pressure techniques employ processes that create dilute (solid) solutions sample (ESI, APCI, APPI, AP-MALDI). This chapter deals with manifold and interfaces allowing overcome these limitations, have developed at breathtaking pace within short time since publication first edition book.