作者: Ingo Dreyer
DOI: 10.1101/2021.04.01.438083
关键词:
摘要: Homeostasis in living cells refers to the steady state of internal, physical, and chemical conditions. It is maintained by self-regulation dynamic cellular system. In order gain insight into homeostatic mechanisms that keep cytosolic nutrient concentrations plant within a range, I performed computational cell biology experiments. Systems membrane transporters were modelled mathematically followed simulation their dynamics. The detailed analyses what-if scenarios demonstrate single transporter type for nutrient, irrespective whether it channel or co-transporter, not sufficient set desired concentration. A cannot flexibly react on different external At least two types same are required, which energized differently. flexibility adjusting concentration was accompanied establishment energy-consuming cycles at suggesting these sometimes called futile as they appear. This understanding may help future design new strategies increasing use efficiency crop plants taking account complex interplay networks level. One sentence summaryFirst principles transport explain why maintenance constant often cycling across membrane.