Renoprotective Effects of Sesamol in Ferric Nitrilotriacetate-Induced Oxidative Renal Injury in Rats
作者： Amit Gupta , Sameer Sharma , Indupal Kaur , Kanwaljit Chopra
DOI: 10.1111/J.1742-7843.2009.00381.X
关键词:
摘要: The present study was designed to investigate the renoprotective effect of 3,4-methylenedioxyphenol (sesamol) on ferric nitrilotriacetate-induced renal toxicity. Rats were pretreated with sesamol (2, 4 and 8 mg/kg, p.o.) 30 min. prior administration nitrilotriacetate (8 mg iron/kg, i.p.) determine blood urea nitrogen serum creatinine levels along oxidative stress. Challenge markedly increased levels, which coupled a marked lipid peroxidation, reduced activity glutathione decreased total nitric oxide in rat kidneys. It also produced significant morphological alterations tumour necrosis factor-alpha levels. Pretreatment significantly restored attenuated normal morphology Present findings strongly suggest pivotal role stress dysfunction points towards potential pathologies.
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