Multicentric hepatic EBV-associated smooth muscle tumors in an AIDS patient: a case report, investigation of mTOR activation and review of the literature
作者： Qi Shen , Wei Feng , Michael S Long , Xiuzhen Duan , Siraya Jaijakul
DOI:
关键词:
摘要: Epstein-Barr virus (EBV) - associated smooth muscle tumors (EBV-SMT) are a rare, recently recognized distinct group of mesenchymal that develop exclusively in patients with immunosuppression. It is believed tumorigenesis is, at least part, through the activation Akt/mammalian target rapamycin (mTOR) signal pathway. We describe clinicopathologic and immunohistochemical features multifocal hepatic EBV-SMT 34-year-old acquired immunodeficiency syndrome (AIDS) patient investigate status mTOR pathway this tumor. In addition, we provide review literature on findings adult AIDS patients, discuss their biologies possible therapeutic strategies.
tmc.edu参考文章(33)
Marina K. Holz, Bryan A. Ballif, Steven P. Gygi, John Blenis, mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events Cell. ,vol. 123, pp. 569- 580 ,(2005) , 10.1016/J.CELL.2005.10.024
W. Timens, A. Boes, H. Vos, S. Poppema, TISSUE DISTRIBUTION OF THE C3D/EBV-RECEPTOR - CD21 MONOCLONAL-ANTIBODIES REACTIVE WITH A VARIETY OF EPITHELIAL-CELLS, MEDULLARY THYMOCYTES, AND PERIPHERAL T-CELLS Histochemistry and Cell Biology. ,vol. 95, pp. 605- 611 ,(1991) , 10.1007/BF00266748
Prashanth T. Bhaskar, Nissim Hay, The two TORCs and Akt. Developmental Cell. ,vol. 12, pp. 487- 502 ,(2007) , 10.1016/J.DEVCEL.2007.03.020
Giovanni Stallone, Antonio Schena, Barbara Infante, Salvatore Di Paolo, Antonella Loverre, Giulio Maggio, Elena Ranieri, Loreto Gesualdo, Francesco Paolo Schena, Giuseppe Grandaliano, Sirolimus for Kaposi's sarcoma in renal-transplant recipients. The New England Journal of Medicine. ,vol. 352, pp. 1317- 1323 ,(2005) , 10.1056/NEJMOA042831
Alec E. Wittek, Charles D. Mitchell, Gary R. Armstrong, Adriana Albini, George R. Martin, Ruth Seemann, Inessa S. Levenbook, Dale E. Wierenga, Jeanette Ridge, Ruth C. Dunlap, Marilyn L. Lundquist, Ronald G. Steis, Dan L. Longo, Jacqueline Muller, Gerald V. Quinnan, Propagation and properties of Kaposi's sarcoma-derived cell lines obtained from patients with AIDS: Similarity of cultured cells to smooth muscle cells AIDS. ,vol. 5, pp. 1485- 1493 ,(1991) , 10.1097/00002030-199112000-00011
Sabah Boudjemaa, Fran�oise Boman, Vincent Guigonis, Liliane Boccon-Gibod, Brain involvement in multicentric Epstein-Barr virus-associated smooth muscle tumours in a child after kidney transplantation. Virchows Archiv. ,vol. 444, pp. 387- 391 ,(2004) , 10.1007/S00428-004-0975-7
Andrea T Deyrup, Victor K Lee, Charles E Hill, Wah Cheuk, Han Chong Toh, Sittampalam Kesavan, Errol Wei??en Chan, Sharon W Weiss, Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients. The American Journal of Surgical Pathology. ,vol. 30, pp. 75- 82 ,(2006) , 10.1097/01.PAS.0000178088.69394.7B
Sheila Henderson, Martin Rowe, Chris Gregory, Debbie Croom-Carter, Fred Wang, Richard Longnecker, Elliott Kieff, Alan Rickinson, Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death. Cell. ,vol. 65, pp. 1107- 1115 ,(1991) , 10.1016/0092-8674(91)90007-L
A. Sodhi, S. Montaner, V. Patel, J. J. Gomez-Roman, Y. Li, E. A. Sausville, E. T. Sawai, J. S. Gutkind, Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 4821- 4826 ,(2004) , 10.1073/PNAS.0400835101
M Okano, G M Thiele, J R Davis, H L Grierson, D T Purtilo, Epstein-Barr virus and human diseases: recent advances in diagnosis. Clinical Microbiology Reviews. ,vol. 1, pp. 300- 312 ,(1988) , 10.1128/CMR.1.3.300