Biological Diversity and Molecular Plasticity of FIC Domain Proteins.

摘要: The ubiquitous proteins with FIC (filamentation induced by cyclic AMP) domains use a conserved enzymatic machinery to modulate the activity of various target posttranslational modification, typically AMPylation. Following intensive study general properties domain catalysis, diverse molecular activities and biological functions these remarkably versatile are now being revealed. Here, we review diversity summarize underlying structure-function relationships. original most abundant genuine bacterial toxins that interfere physiology in various, yet ill-defined, contexts. Host-targeted virulence factors have evolved repeatedly out this pool exaptation for manipulation host cell signaling favor pathogens. single human protein HypE (FICD) has specific function regulation stress responses.