Intra-arterial chemotherapy for retinoblastoma: report No. 2, treatment complications.

摘要: Objective To describe treatment complications following intra-arterial chemotherapy (IAC) for retinoblastoma. Methods A retrospective interventional series of ophthalmic artery cannulation IAC injection (3 planned sessions at 1-month intervals) was undertaken. Thirty-eight catheterizations 17 eyes patients were performed from September 2008 to 2010. Fluoroscopy the before and immediately after treatment. Heparin given during procedure aspirin (40 mg) orally 1 week. The determined. Results Only 190 children selected with this period. Following successful in 16 cases, there no evidence metastasis, stroke, brain injury, or persistent systemic toxic effects. demonstrated patent each case. therapy, orbital adnexal findings month included eyelid edema (n = 13), blepharoptosis (n = 10), cilia loss (n = 1), congestion temporary dysmotility (n = 12). These resolved within 6 months all cases. vascular stenosis (permanent 3 case), confirmed on fluoroscopy Concomitant central branch retinal occlusion noted 2 case). Subtle pigment epithelial mottling 9 cases that slowly evolved later-onset underlying choroidal atrophy 5 noted. Conclusions Treatment retinoblastoma can lead mild severe short-term ocular complications, including as well potentially blinding obstruction. This should be used caution.