Residual vein obstruction as a predictor for recurrent thromboembolic events after a first unprovoked episode: data from the REVERSE cohort study

作者: G. LE GAL , M. CARRIER , M. J. KOVACS , M. T. BETANCOURT , S. R. KAHN

DOI: 10.1111/J.1538-7836.2011.04240.X

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摘要: See also Watson HG. RVO – Real value obscure. This issue, pp 1116–8; Carrier M, Rodger MA, Wells PS, Righini Le Gal G. Residual vein obstruction to predict the risk of recurrent venous thromboembolism in patients with deep thrombosis: a systematic review and meta-analysis. 1119–25. Summary. Objectives: There is growing interest using residual (RVO) guide duration oral anticoagulant therapy (OAT) for unprovoked thrombosis (DVT). We sought determine if as determined by compression ultrasonography (CUS) after completion 5–7 months anticoagulation DVT associated an increased (VTE). Materials Methods: This was multicentre multinational prospective cohort study undertaken tertiary care centers. Patients first ‘unprovoked’ major VTE were enrolled over 4-year period completed mean 18-month follow-up September 2006. All 452 had baseline CUS at inclusion assess any before stopping OAT 5–7 months. During off OAT, all episodes suspected independently adjudicated reference imaging. Results: Forty-five out 231 abnormal (19.5%) during follow-up, compared 32 220 normal (14.6%), one patient inadequate CUS. There no significant association between VTE: hazard ratio 1.4 (95% confidence interval, 0.9–2.1), P = 0.19. None different degrees clot resolution on statistically significantly VTE. Conclusion: In our study, presence time withdrawal not higher assessment may be useful anticoagulation.

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